lunedì 27 maggio 2013

The Weighted Means: Essential Bibliography

In the next weeks I will treat the last and more complicated method to analyze the data: the weighted mean. The general hypothesis is that a relatively high number of experiment will be performed (my suggestion: n>5, although it is not so restrictive), and so the method is complimentary to that treated as simple approach – experiment as a random factor.

I have partially treated the argument in:

Goldoni M, Tagliaferri S. Dose-response or dose-effect curves in in vitro experiments and their use to study combined effects of neurotoxicants. Methods Mol Biol. 2011;758:415-34. doi: 10.1007/978-1-61779-170-3_28. Review. PubMed PMID: 21815082  

But I will re-treat the argument step by step to completely explain all the passages. Most of them are available in this essential bibliography:

1)      JR Taylor. An introduction to error analysis:  the study of uncertainties in physical measurements. University Science Books, 1997.

I will adapt the passages proposed for physical measures to toxicology (Chapter in the book entitled: Weighted Means, chapter 7 in the 2nd edition).

2)      Bland, J. M., and Kerry, S. M. (1998) Weighted comparison of means, BMJ. 316, 129.

This is a very brief but  interesting lecture taken from clinics. http://www.bmj.com/content/316/7125/129

Good Luck!!

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